Collaborative procurement and private-sector housebuilding and refurbishment works: A pilot study investigation of the UK

Purpose Framed as a pilot study, the purpose of this paper is to study the perceived appropriateness of an existing collaborative procurement procedures (CPP) framework from the housebuilder’s perspective; seeking to improve its utility and stimulate further exploration. Design/methodology/approach Informed by an existing CPP framework, and conducted by a UK-based development professional, four in-depth semi-structured interviews were undertaken with senior housebuilding practitioners from London and surrounding counties. A qualitative analysis was then conducted for this sociological study. Findings Perceived appropriateness of the framework was high; however, a number of procedural improvements were identified, along with limitations. Future studies are recommended including the influence upon project performance of groundworker integration at the design stage. Research limitations/implications Limited to four interviews from one regional area, the study is an initial insight into the appropriateness of an existing CPP framework. Insights into why CP uptake is marginal within housebuilding were also gained. The research purpose was achieved but by offering a self-reflection upon practice (vis-à-vis wider generalisations) the findings provide a springboard for further studies. Practical implications The research identifies with current practice, industry perceptions, and paths towards improving the utility of the CPP framework. Social implications This study offers insights into the perceptions of private housebuilding practitioners of their own practices and the factors they find challenging within the social constructs of their industry. Originality/value This research constitutes one of the first studies in the UK to examine the CPP framework from the perspective of the private housebuilder and is undertaken with the express purpose of furthering that framework’s utility

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe